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Combretastatin A-2 Synthetic Modifications


Abstract Combretastatin A-4 (CA-4) represents one of the most promising antineoplastic and cancer vascular targeting stilbenes that have been isolated from the South African bush willow, Combretum Caffrum Kuntze. In order to further explore the bioactivity of this molecule, a diiodo derivative of CA-4, as well as its phosphate prodrug, was synthesized and analyzed for its biological activity; although only a scale up synthesis of this compound was performed herein for ongoing analysis. In general, no increased specificity was noted for the human cancer cell lines. Antiangiogenic properties were similar to the untreated control. The diiodocombstatin was active against M. luteus, and its phosphate prodrugs were very active against N. gonorrhoeae. ... (more)
Created Date 2011
Contributor Trickey-Platt, Brindi (Author) / Pettit, George R (Advisor) / Moore, Ana (Committee member) / Skibo, Edward (Committee member) / Arizona State University (Publisher)
Subject Organic Chemistry / Chemistry
Type Masters Thesis
Extent 67 pages
Language English
Copyright
Reuse Permissions All Rights Reserved
Note M.S. Chemistry 2011
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS


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Description Dissertation/Thesis