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The Effects of Age, Hormone Loss, and Estrogen Treatment on Spatial Cognition in the Rat: Parameters and Putative Mechanisms

Abstract Cognitive function is multidimensional and complex, and research indicates that it is impacted by age, lifetime experience, and ovarian hormone milieu. One particular domain of cognitive function that is susceptible to age-related decrements is spatial memory. Cognitive practice can affect spatial memory when aged in both males and females, and in females alone ovarian hormones have been found to alter spatial memory via modulating brain microstructure and function in many of the same brain areas affected by aging. The research in this dissertation has implications that promote an understanding of the effects of cognitive practice on aging memory, why males and females respond differently to cognitive practice, and the parameters and mechan... (more)
Created Date 2011
Contributor Talboom, Joshua Siegfried (Author) / Bimonte-Nelson, Heather A (Advisor) / Conrad, Cheryl D (Committee member) / Neisewander, Janet L (Committee member) / West, Stephen G (Committee member) / Arizona State University (Publisher)
Subject Neurosciences / Behavioral Sciences / Biology / Aging / Behavioral Neuroscience / Cognitive Practice / Hormone Therapy / Learning and Memory / Rat
Type Doctoral Dissertation
Extent 336 pages
Language English
Reuse Permissions All Rights Reserved
Note Ph.D. Psychology 2011
Collaborating Institutions Graduate College / ASU Library
Additional Formats MODS / OAI Dublin Core / RIS

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Description Dissertation/Thesis